The Efficacy of Licensed-Indication Use of Donepezil and Memantine Monotherapies for Treating Behavioural and Psychological Symptoms of Dementia in Patients with Alzheimers Disease: Systematic Review and Meta-Analysis
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Background/Aims: Behavioural and psychological symptoms of dementia (BPSD) in Alzheimer’s disease (AD) greatly increase caregiver burden. The abilities of donepezil and memantine to manage BPSD within their licensed indications in AD were compared. Methods: A systematic review, random effects meta-analysis and Bucher indirect comparison were conducted. Results: Six randomised controlled studies (4 donepezil and 2 memantine) reported use within the licensed indication and had Neuropsychiatric Inventory (NPI) data suitable for meta-analysis. BPSD showed significant improvement with donepezil compared with placebo [weighted mean difference (WMD) in NPI –3.51, 95% confidence interval (CI) –5.75, –1.27], whereas this was not the case for memantine (WMD –1.65, 95% CI –4.78, 1.49). WMD in NPI for donepezil versus memantine favoured donepezil but was not statistically significant (–1.86, 95% CI –5.71, 1.99; p = 0.34). Conclusion: Within its licensed indication, donepezil is efficacious for the management of BPSD in AD compared with placebo. Copyright © 2011 S. Karger AG, Basel Published online: July 20, 2011 E X T R A I.A. Lockhart This is an Open Access article licensed under the terms of the Creative Commons AttributionNonCommercial-NoDerivs 3.0 License (www.karger.com/OA-license), applicable to the online version of the article only. Distribution for non-commercial purposes only. Pfizer Ltd., Walton Oaks Dorking Road, Walton-on-the-Hill Tadworth KT20 7NS (UK) Tel. +44 1737 330 573, E-Mail ian.lockhart @ pfizer.com www.karger.com/dee DOI: 10.1159/000330032 D ow nl oa de d by : 54 .7 0. 40 .1 1 10 /1 7/ 20 17 7 :1 2: 39 P M 213 Dement Geriatr Cogn Disord Extra 2011;1:212–227 DOI: 10.1159/000330032 E X T R A Lockhart et al.: BPSD Outcomes for Donepezil versus Memantine www.karger.com/dee © 2011 S. Karger AG, Basel Published online: July 20, 201
منابع مشابه
The Efficacy of Licensed-Indication Use of Donepezil and Memantine Monotherapies for Treating Behavioural and Psychological Symptoms of Dementia in Patients with Alzheimer's Disease: Systematic Review and Meta-Analysis
BACKGROUND/AIMS Behavioural and psychological symptoms of dementia (BPSD) in Alzheimer's disease (AD) greatly increase caregiver burden. The abilities of donepezil and memantine to manage BPSD within their licensed indications in AD were compared. METHODS A systematic review, random effects meta-analysis and Bucher indirect comparison were conducted. RESULTS Six randomised controlled studie...
متن کاملThe Efficacy of Licensed-Indication Use of Donepezil and Memantine Monotherapies for Treating Behavioural and Psychological Symptoms of Dementia in Patients with Alzheimers Disease: Systematic Review and Meta-Analysis
Background/Aims: Behavioural and psychological symptoms of dementia (BPSD) in Alzheimer’s disease (AD) greatly increase caregiver burden. The abilities of donepezil and memantine to manage BPSD within their licensed indications in AD were compared. Methods: A systematic review, random effects meta-analysis and Bucher indirect comparison were conducted. Results: Six randomised controlled studies...
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